I can't promise this is "only the best", but I'm an avid listener to The Splendid Table and think it deserves a high rating. Each week the show features a Road Food segment by Jane and Michael Stern, a couple of interviews with some writer or chef or food explorer, a trivia challenge and a (pre-recorded) call-in section where Lynne answers questions. I swear I've gained 10 lbs since I started listening to that show.
The Splendid Table now can be downloaded in podcast form. Follow this link to get to their podcast page; otherwise, if you just go to The Splendid Table's home page you'll find a link to that week's show podcast.