Cockscomb which was on Eater's heatmap last year. I've been to Chris Cosentino's previous restaurant, Incanto, a few times and absolutely loved it (also his small place Boccalone at the ferry building market). Casual atmosphere, nose to tail eating, amazing charcuterie, a black board with interesting specials that change everyday. The new place has seafood as well and I am absolutely dying to go.
Then for cocktails you have to visit Martin Cate's new place Whitechapel which is devoted to gin...