Quinine the primary ingredient in tonic water (notable for its use in treating malaria) is quite bitter. The bitter taste led to the invention of the gin and tonic, using the gin to cover up the taste of the quinine in the tonic water (the quinine concentration was once much higher - modern stuff would have little therapeutic properties). You might also be able to source some Cinchona tree bark from which quinine is isolated. As the previous poster mentioned bitter melon is extremely bitter, personally I can't stand it but maybe I don't prepare it well, even with a good amount of fatty pork. edit: cocoa/chocolate is also quite bitter when unsweeted wikipedia has a link to various bitter compounds here: http://en.wikipedia.org/wiki/Category:Bitter_compounds