Lafayette is also my hometown. I second Fist's list for the most part, though some places are new since I left the state several years ago. I would underline Cafe Vermilionville, Dwyer's, Old Tyme Grocery (fried shrimp poboy is a must!), and Blue Dog. I'd also add Charley G's for grilled seafood. Once you have french bread in Louisiana, you'll wonder what the hell everyone else around the US is trying to serve you -- a sour dough baguette, maybe? Try Poupart's bakery on Pinhook. What's hard about making suggestions for restaurants in Louisiana is what to suggest about things like gumbo and crawfish etoufee. To me these homier dishes will always be best in someone's Mama's kitchen. I don't think I've ever even ordered gumbo in a restaurant cuz I know I'd rather my own or my Mama's. Also, as for things to do in Lafayette -- music lovers should check out the Blue Moon Guest House and Saloon. It's a cool, funky place downtown that's part hostel part dance hall. Good Cajun/Zydeco/whatever music.