I recently had lunch at Quique Dacosta in Denia, Spain (it was amazing). As the town is quite remote (1 hour drive from Valencia), the only feasible way to get there is by renting a car. After having the wine pairing, it would be unsafe to attempt to drive back. Fortunately the weather was warm and we were able to take a dip in the Mediterranean and nap on the beach for a few hours before driving back.
How would one handle sobering up after other remotely-located restaurants like French Laundry, El Celler de Can Roca, or Osteria Francescana? Do you get a local hotel? For lunch, this seems less ideal than dinner, especially if the town is not particularly exciting like Denia and you don't want to spend that much time there. Spending a night in Yountville and seeing Napa Valley wouldn't be so bad.
Steven Shaw hired a van with driver to go to El Bulli and back.
In a pinch, one could nap in the car for a while.