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Curcumin, which provides the yellow color in curry, may activate a key enzyme
Washington, DC -- A new study has found that curry, a common and popular cooking additive, could be an effective enhancer of an enzyme that protects the brain against oxidative conditions. This research is an important first step in determining whether curry could be preventive agent against acute neurodegenerative conditions, or reducing the progression of chronic and age associated neurodegenerative disorders, such as Alzheimer's disease.
Free Radicals and Neurodegenerative Disease
One of the most prominent current theories of aging is the "free radical theory." According to this theory, free radical molecules generated through mitochondrial metabolism can act as causative factor of abnormal function and cell death. Various toxins in the environment can injure mitochondrial enzymes, leading to increased generation of free radicals and oxidative stress, that over the life-span would eventually play a major role in aging. Free radical's oxidative damage to key intracellular targets such as DNA or proteins has been shown to be a major cause of the degenerative diseases related to aging such as cancer and Alzheimer's disease.
At the same time, a number of studies have supported the beneficial effects of some commonly used natural products in preventing various pathologic conditions. Spices and herbs often contain phenolic substances with potent antioxidative and chemopreventive properties. Among them is curcumin, a natural phenolic agent, extracted from the rhizome of Curcuma Longa, and the yellow pigment in curry, strongly induced HO-1 expression and activity in rat astrocytes.
Conclusions
This study identifies a novel compound that could be used for therapeutic purposes as potent inducers of HO-1 for protecting brain cells against oxidative conditions. The researchers believe that additional in vitro and in vivo studies are necessary to determine whether curcumin can be used as preventive agent against acute neurodegenerative conditions that affect an increasingly aged population.
The American Physiological Society (APS) is America's oldest biomedical sciences research society. The not-for-profit society, with some 11,000 members, is the publisher of 14 scientific journals, including the American Journal of Physiology, which has been published since 1898.
Edited by Episure, 22 April 2004 - 10:22 AM.
